First, the error; second, the question.

I tried to upgrade to the latest version 5.0.x, but I encountered a recurring installation error during the process. I have attached a screenshot of the error for your reference.
Whenever I run BleachBit, the size and positions of my desktop icons are completely reset or changed. I never experienced this issue while using CCleaner, so I find it quite frustrating. Which specific option in BleachBit should I uncheck to prevent this from happening again?

Error opening file for writing

C\Users\xxx\AppDate\L:ocal\BleachBit\-ctypes.pyd

Click Abort to stop the installation..........

( I tride to install 5.0.2.3065)